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The analogy drawn between running a lab and a small business is a good one. And I completely concur with your call to diversify post-graduate Science education. A similar call has come out in Nature Jobs through the new Recruiters column. Michael Alverez, from the Stanford Medical School Career Center in particular, appears to be mirroring your suggestion that researchers learn more in their training than simply how to pippet and run gels.
Geoff, I'd also be interested in learning about any sources of information you may find on the history of federal R&D funding.